16/02/2018
Human Brain Mapping • Singapore • June 17-21, 2018

2018 OHBM annual meeting
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15/02/2018
European Congress of Radiology (ECR) • Symposium, Saturday, March 3, 2018

Psychoradiology: a blend of molecular, functional and structural imaging with a taste of psychology 16:00-17:30, Room E2 Online videos are available, just click on the titles of the talks:
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15/02/2018
PING workshop Munich • May 16-17th 2018

Topic: The individual Human Connectome
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Non-invasive transcranial electrical stimulation of the prefrontal cortex using multimodal MRI

workgroup

Non-invasive transcranial brain stimulation (NIBS) methods such as prefrontal transcranial direct current stimulation (tDCS) provide a unique in vivo intervention for probing the functional role of regions and hubs in human neural systems that play a role in the pathophysiology of psychiatric disorders. Recent research has shown that the individual human brain functional MRI connectivity (fcMRI) shows different within-subject variability than the variability found between subjects. Anatomical targeted analyses of NIBS in neuropsychiatric patients and healthy subjects have generated promising results. Even combining several neuroimaging methods may be useful to detect classifiers that can be reliable used to predict NIBS effects.

own work:
Wörsching J, Padberg F, Helbich K, Hasan A, Koch L, Goerigk S, Stoecklein S, Ertl-Wagner B, Keeser D. Test-retest reliability of prefrontal transcranial Direct Current Stimulation (tDCS) effects on functional MRI connectivity in healthy subjects. NeuroImage. Available online 24 April 2017, http://doi.org/10.1016/j.neuroimage.2017.04.052.  PDF     

Wörsching J, Padberg F, Ertl-Wagner B, Kumpf U, Kirsch B, Keeser D. Imaging transcranial direct current stimulation (tDCS) of the prefrontal cortex-correlation or causality in stimulation-mediated effects? Neuroscience & Biobehavioral Reviews. 2016;69:333-56.  PDF 

Palm, U*, Keeser, D*, Hasan, A, Kupka, M, Blautzik, J, Sarubin, N, Kaymakanova, F, Unger, I, Kupka, MJ, Falkai, P, Ertl-Wagner, B,, Padberg, F. Transcranial direct current stimulation (tDCS) changes negative symptoms and resting-state functional MRI connectivity in schizophrenia: A double-blind, sham-controlled, clinical trial. Schizophrenia Bulletin. 2016 Sep;42(5):1253-61. PDF   

Keeser, D, Meindl, T, Bor, J, Reiser, M, Palm, U, Pogarell, O, Mulert, C, Padberg, F. Prefrontal transcranial Direct Current Stimulation (tDCS) mudulates resting-state functional connectivity in healthy subjects: a functional magnetic resonance imaging (fMRI) study. Journal of Neuroscience. 2011 Oct 26;31(43):15284-93. 
                                      
Keeser D, Padberg F, Reisinger E, Pogarell O, Kirch V, Palm U, Karch S, Möller HJ, Nitsche MA, Mulert C (2011). Prefrontal direct current stimulation modulates resting EEG and  event-related  potentials  in healthy subjects: A standardized low resolution tomography (sLORETA) study. NeuroImage 55(2): 644-657. PDF
 

Neurofeedback

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Own work:
Engelbregt, H, Keeser, D, Suiker, EM, Eichborn, D, Karch, S, Deijen, JB & Pogarell, O. Long-term effects of placebo-controlled prefrontal EEG-neurofeedback training in healthy subjects. Clinical Neurophysiology. 2016 Apr. 127(4):1931-7.  PDF

Karch S*, Keeser D*, Hümmer S, Paolini M, Kirsch V, Karali T, Kupka M, Rauchmann BS, Chrobok A, Blautzik J, Koller G, Ertl-Wagner B, Pogarell O. Modulation of Craving Related Brain Responses Using Real-Time fMRI in Patients with Alcohol UseDisorder. PLoS One. 2015 Jul 23;10(7).  PDF        
*equal contribution.
 

Exercise

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Own work:
Papiol S*, Popovic D*, Keeser D, Hasan A, Schneider-Axmann T, Degenhardt F, Rossner MJ, Bickeböller H, Schmitt A, Falkai P, Malchow B. Polygenic risk has an impact on the structural plasticity of hippocampal subfields during aerobic exercise combined with cognitive remediation in multi-episode schizophrenia. Transl Psychiatry. 2017 Jun 27;7(6):e1159.  PDF                 
*equal contribution. 

Malchow B*, Keeser D*, Keller K, Hasan A, Rauchmann BS, Kimura H, Schneider-Axmann T, Dechent P, Gruber O, Ertl-Wagner B, Honer WG, Hillmer-Vogel U, Schmitt A, Wobrock T, Niklas A, Falkai P. Effects of endurance     training on brain structures in chronic schizophrenia patients and healthy controls. Schizophrenia Research. 2016 Jun;173(3):182-91. PDF  
*equal contribution
 

Experimental pharmaco fMRI

workgroup

Blautzik, J, Keeser, D, Kirsch, V, Berman, A, Paolini, M, Mueller, S, Coates, U, Reiser, M, Teipel, SJ, Meindl, T. Divergent effects of long-term treatment with Galantamine on the Default-Mode-Network in patients with Alzheimer Disease. European Neuropsychopharmacology. 2015 Dec 10. 26(3):602-13.  PDF

Mueller S, Costa A, Keeser D, Pogarell O, Berman A, Coates U, Reiser MF, Riedel M, Möller HJ, Ettinger U, Meindl T. The effects of methylphenidate on whole brain intrinsic functional connectivity (2014). Human Brain Mapping; 35(11):5379-5388.  PDF
 

Circadian rhythm

Blautzik J, Vetter C, Schneider A, Gutyrchik E, Reinisch V, Keeser D, Paolini M, Pöppel E, Bao Y, Reiser M, Roenneberg T, Meindl T. Dysregulated daily rhythmicity of neuronal resting-state networks in MCI patients. Chronobiology International. 2014 Nov. 31(9):1041-50.  PDF   

Blautzik J, Vetter C, Peres I, Gutyrchik E, Keeser D, Berman A, Kirsch V, Mueller S, Pöppel E, Reiser M, Roenneberg T, Meindl T. Classifying fMRI-derived resting-state connectivity patterns according to their daily rhythmicity. Neuroimage. 71:298-306.  PDF